Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8483096 | 1.00 | NAMPT (0.43) | NAMPTMEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL8552537 | 0.85 | CYP11B1 (0.43) | MEN1KMT2ACYP3A4CYP19A1PTAFR | |
| SCHEMBL8477182 | 0.85 | CYP11B1 (0.43) | MEN1KMT2ACYP3A4CYP19A1PTAFR | |
| SCHEMBL8552140 | 0.81 | MEN1 (0.45) | MEN1KMT2ACYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8476865 | 0.81 | MEN1 (0.45) | MEN1KMT2ACYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8117055 | 0.81 | GRIN1 (0.43) | MEN1KMT2ACYP3A4CYP2D6ADRB1 | |
| SCHEMBL8483060 | 0.81 | MEN1 (0.42) | MEN1KMT2ACYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8118428 | 0.81 | MEN1 (0.42) | MEN1KMT2ACYP3A4CYP2D6CYP19A1 | |
| SCHEMBL8118260 | 0.81 | MEN1 (0.42) | MEN1KMT2ACYP3A4CYP2D6CYP19A1 | |
| SCHEMBL7766546 | 0.79 | CYP3A4 (0.39) | NAMPTMEN1KMT2ACYP3A4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |