Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7707825 | 0.84 | ROCK2 (0.57) | KDM4EHTTMAPTALDH1A1ROCK2 | |
| SCHEMBL8554376 | 0.76 | ROCK2 (0.56) | KDM4EMAPTROCK2LMNASMN1; SMN2 | |
| SCHEMBL7701986 | 0.75 | ROCK2 (0.54) | KDM4EHTTMAPTALDH1A1ROCK2 | |
| SCHEMBL18073895 | 0.75 | ROCK2 (0.56) | KDM4EMAPTALDH1A1ROCK2LMNA | |
| SCHEMBL8556812 | 0.73 | ROCK2 (0.60) | KDM4EMAPTALDH1A1ROCK2LMNA | |
| SCHEMBL27483791 | 0.72 | KDM4E (0.46) | KDM4EHPGDHSD17B10KMT2AALDH1A1 | |
| SCHEMBL8556446 | 0.72 | SCD (0.41) | KDM4EHPGDHTTHSD17B10MAPT | |
| SCHEMBL7423432 | 0.71 | KMT2A (0.62) | KDM4EHPGDHTTHSD17B10KMT2A | |
| SCHEMBL27528020 | 0.71 | CYP1A2 (0.43) | KDM4EHSD17B10KMT2AALDH1A1MEN1 | |
| SCHEMBL8555167 | 0.70 | ROCK2 (0.63) | KDM4EHTTMAPTALDH1A1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0820441-A1 | INDOLE DERIVATIVES AS cGMP-PDE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-01-28 | — | — | EP | disclosed |