Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.59 |
| ▸ | BCHE | P06276 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BACE1 | P56817 | 1/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | CCR5 | P51681 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.53 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8555329 | 0.99 | MAPT (0.68) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL8551099 | 0.95 | MAPT (0.66) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8550717 | 0.94 | MAPT (0.65) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL8552870 | 0.89 | MAPT (0.71) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8549701 | 0.88 | MAPT (0.69) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL8549295 | 0.88 | MEN1 (0.64) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL8551720 | 0.88 | SIGMAR1 (0.60) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8686857 | 0.87 | MEN1 (0.62) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8553181 | 0.87 | SIGMAR1 (0.59) | MAPTPOLBCYP2C9CYP2C19SIGMAR1 | |
| SCHEMBL8550490 | 0.86 | BCHE (0.65) | BCHEACHECHRM2CHRM3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |