Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | CCR3 | P51677 | 1/20 | 0.58 |
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8549701 | 0.99 | MAPT (0.69) | MAPTALDH1A1CCR3SCN1ASCN2A | |
| SCHEMBL8551183 | 0.89 | SCN1A (0.68) | MAPTALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL8551863 | 0.89 | MAPT (0.69) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL8551099 | 0.89 | MAPT (0.66) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8553929 | 0.88 | SCN1A (0.66) | MAPTALDH1A1SCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL8555329 | 0.88 | MAPT (0.68) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| Hydrochloric Acid SCHEMBL8550717 | 0.88 | MAPT (0.65) | MAPTALDH1A1POLBCYP2C9CYP2C19 | |
| SCHEMBL8553740 | 0.87 | ALDH1A1 (0.60) | MAPTALDH1A1SCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL8555461 | 0.86 | ALDH1A1 (0.59) | MAPTALDH1A1SCN1ASCN2ASCN3A | |
| SCHEMBL8551160 | 0.85 | SCN1A (0.61) | SCN1ASCN2ASCN3AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |