Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.38 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8551775 | 0.77 | MAPT (0.42) | APPMAPTSNCACTRCEP300 | |
| Trifluoroacetic Acid SCHEMBL8547172 | 0.73 | MAPT (0.37) | APPMAPTSNCACTRCEP300 | |
| SCHEMBL8322706 | 0.72 | MAPT (0.64) | APPMAPTSNCACTRCRET | |
| SCHEMBL8320829 | 0.72 | MAPT (0.64) | APPMAPTSNCACTRCRET | |
| SCHEMBL8551592 | 0.72 | CYP1A2 (0.39) | APPMAPTSNCACTRCEP300 | |
| SCHEMBL8320828 | 0.71 | MAPT (0.62) | APPMAPTSNCACTRCRET | |
| SCHEMBL2063144 | 0.70 | ITGA4 (0.46) | APPMAPTSNCAEP300HPGD | |
| SCHEMBL2063145 | 0.70 | ITGA4 (0.46) | APPMAPTSNCAEP300HPGD | |
| SCHEMBL8549389 | 0.70 | PDGFRB (0.37) | APPMAPTSNCACTRCEP300 | |
| SCHEMBL8325317 | 0.65 | MAPT (0.70) | APPMAPTSNCACTRCHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |