Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.34 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549389 | 0.81 | PDGFRB (0.37) | APPMAPTSNCAPPARGEP300 | |
| SCHEMBL8321785 | 0.75 | MAPT (0.56) | KDM4EAPPMAPTSNCAPPARG | |
| Hydrochloric Acid SCHEMBL8551775 | 0.72 | MAPT (0.42) | LMNAMEN1KMT2AAPPMAPT | |
| SCHEMBL8551906 | 0.72 | APP (0.40) | APPMAPTSNCAPPARGEP300 | |
| Trifluoroacetic Acid SCHEMBL8547172 | 0.70 | MAPT (0.37) | APPMAPTSNCAEP300SIRT2 | |
| SCHEMBL10757421 | 0.68 | ADRB2 (0.50) | CYP1A2AGTR1LMNA | |
| SCHEMBL10757414 | 0.68 | ADRB2 (0.50) | CYP1A2AGTR1LMNA | |
| SCHEMBL8327034 | 0.67 | FLT3 (0.44) | APPMAPTSNCANTRK1CTRC | |
| SCHEMBL2063145 | 0.66 | ITGA4 (0.46) | LMNAMEN1KMT2AAPPMAPT | |
| SCHEMBL2063144 | 0.66 | ITGA4 (0.46) | LMNAMEN1KMT2AAPPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |