Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | BUB1 | O43683 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.33 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.33 |
| ▸ | CTRC | Q99895 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | PRKACA | P17612 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551592 | 0.81 | CYP1A2 (0.39) | APPMAPTSNCAEP300SIRT2 | |
| SCHEMBL8323929 | 0.74 | MAPT (0.55) | PDGFRBKDRAPPMAPTSNCA | |
| Hydrochloric Acid SCHEMBL8551775 | 0.70 | MAPT (0.42) | APPMAPTSNCAEP300SIRT2 | |
| SCHEMBL8551906 | 0.70 | APP (0.40) | PDGFRBAPPMAPTSNCAEP300 | |
| Trifluoroacetic Acid SCHEMBL8547172 | 0.69 | MAPT (0.37) | APPMAPTSNCAEP300SIRT2 | |
| SCHEMBL125775 | 0.67 | TOP2B (0.56) | MAPTSIRT2SMN1; SMN2HPGD | |
| SCHEMBL8321785 | 0.65 | MAPT (0.56) | PDGFRBKDRAPPMAPTSNCA | |
| SCHEMBL2063145 | 0.64 | ITGA4 (0.46) | PDGFRBKDRAPPMAPTSNCA | |
| SCHEMBL2063144 | 0.64 | ITGA4 (0.46) | PDGFRBKDRAPPMAPTSNCA | |
| SCHEMBL11757022 | 0.64 | HTR1A (0.61) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719135-A | TYROSINE KINASE INHIBITORS | PHARMACIA S.P.A. (IT) | 1998-02-17 | — | — | US | disclosed |