Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.50 |
| ▸ | EDNRA | P25101 | 4/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547935 | 0.91 | EDNRB (0.43) | EDNRBEDNRAPLA2G2ATP53 | |
| SCHEMBL8549140 | 0.90 | EDNRB (0.48) | EDNRBEDNRADYRK1APLA2G2AALOX5AP | |
| SCHEMBL8549255 | 0.89 | EDNRB (0.47) | EDNRBEDNRADYRK1APLA2G2AMAPT | |
| SCHEMBL8548607 | 0.88 | EDNRB (0.45) | EDNRBEDNRADYRK1APLA2G2APLA2G10 | |
| SCHEMBL8553797 | 0.87 | EDNRB (0.55) | EDNRBEDNRADYRK1APLA2G2AALOX5AP | |
| SCHEMBL8553159 | 0.87 | EDNRB (0.54) | EDNRBEDNRAPLA2G2AMAPTPLA2G10 | |
| SCHEMBL8551472 | 0.85 | EDNRB (0.43) | EDNRBEDNRADYRK1APLA2G2APPARD | |
| SCHEMBL8550986 | 0.85 | EDNRB (0.51) | EDNRBEDNRAMAPTPPARG | |
| SCHEMBL8551981 | 0.85 | EDNRB (0.42) | EDNRBEDNRAPLA2G2AMAPT | |
| SCHEMBL8552726 | 0.85 | EDNRB (0.46) | EDNRBEDNRADYRK1APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |