Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.48 |
| ▸ | EDNRA | P25101 | 5/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551281 | 0.92 | EDNRB (0.49) | EDNRBEDNRAALOX5APTSHRS1PR3 | |
| SCHEMBL8551760 | 0.92 | EDNRB (0.49) | EDNRBEDNRAERN1 | |
| SCHEMBL8551108 | 0.90 | EDNRB (0.50) | EDNRBEDNRAALOX5APDYRK1APLA2G2A | |
| SCHEMBL8549608 | 0.89 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL8551981 | 0.89 | EDNRB (0.42) | EDNRBEDNRATSHRTDP1PLA2G2A | |
| SCHEMBL8547935 | 0.88 | EDNRB (0.43) | EDNRBEDNRATSHRTDP1PLA2G2A | |
| SCHEMBL8548607 | 0.88 | EDNRB (0.45) | EDNRBEDNRADYRK1APLA2G2A | |
| SCHEMBL8548507 | 0.87 | EDNRB (0.54) | EDNRBEDNRATDP1 | |
| SCHEMBL8552514 | 0.87 | EDNRB (0.62) | EDNRBEDNRA | |
| SCHEMBL8551276 | 0.87 | EDNRB (0.61) | EDNRBEDNRAS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |