SCHEMBL8552073

SCHEMBL8552073

OC1CCN(Cc2cccc(F)c2)CC1

nearest known ligand 0.67

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.66
SMN1; SMN2 Q16637 1/20 0.66
MEN1 O00255 2/20 0.62
KMT2A Q03164 2/20 0.62
SIGMAR1 Q99720 5/20 0.60
HSD17B10 Q99714 1/20 0.55
CYP2D6 P10635 1/20 0.52
CYP2C9 P11712 1/20 0.52
ALOX15 P16050 1/20 0.52
TSHR P16473 1/20 0.52
CYP2C19 P33261 1/20 0.52
KDM4E B2RXH2 1/20 0.52
POLB P06746 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25212788 0.91 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL29864671 0.91 ALDH1A1 (0.58) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL16226986 0.84 ALDH1A1 (0.82) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL30089449 0.84 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL6944257 0.84 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL12013927 0.84 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL10989753 0.82 DRD2 (0.60) ALDH1A1SIGMAR1HSD17B10ALOX15KDM4E
SCHEMBL1519149 0.82 SIGMAR1 (0.65) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL5360595 0.81 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1
SCHEMBL12513635 0.81 ALDH1A1 (0.62) ALDH1A1SMN1; SMN2MEN1KMT2ASIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN disclosed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
CN-1183768-A Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 1998-06-03 CN disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed