Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 7/20 | 0.33 |
| ▸ | HTR1D | P28221 | 6/20 | 0.33 |
| ▸ | DRD1 | P21728 | 6/20 | 0.33 |
| ▸ | DRD4 | P21917 | 6/20 | 0.33 |
| ▸ | DRD5 | P21918 | 6/20 | 0.33 |
| ▸ | DRD3 | P35462 | 6/20 | 0.33 |
| ▸ | HTR1B | P28222 | 5/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | STS | P08842 | 3/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549739 | 0.88 | DRD2 (0.46) | DRD2SLC6A4CCR2HTR1AHTR1D | |
| SCHEMBL8552146 | 0.84 | DRD2 (0.39) | DRD2SLC6A4 | |
| SCHEMBL8547937 | 0.82 | DRD2 (0.49) | DRD2SLC6A4CCR2HTR2AHTR7 | |
| SCHEMBL8549361 | 0.82 | DRD2 (0.47) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL7484011 | 0.82 | HTR1D (0.52) | DRD2CCR2HTR6HTR1DHTR1B | |
| SCHEMBL8552297 | 0.81 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8550182 | 0.81 | DRD2 (0.47) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL8550474 | 0.80 | DRD2 (0.41) | DRD2SLC6A4HTR2AHTR7HTR6 | |
| SCHEMBL8702974 | 0.77 | DRD2 (0.53) | DRD2SLC6A4CCR2HTR1DHTR1B | |
| SCHEMBL8546639 | 0.76 | SMN1; SMN2 (0.48) | DRD2SLC6A4CCR2HTR2AHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |