Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 5/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.32 |
| ▸ | GAK | O14976 | 1/20 | 0.32 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.32 |
| ▸ | STK16 | O75716 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.32 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.32 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.32 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551661 | 0.81 | DRD2 (0.43) | DRD2SLC6A4HTR2A | |
| SCHEMBL7481599 | 0.81 | HTR6 (0.49) | DRD2HTR1AHTR6HTR2AHTR7 | |
| SCHEMBL8552149 | 0.80 | DRD2 (0.47) | DRD2SLC6A4HTR1AHTR6HTR2A | |
| SCHEMBL8549739 | 0.79 | DRD2 (0.46) | DRD2SLC6A4HTR1AKCNH2 | |
| SCHEMBL8550058 | 0.78 | DRD2 (0.41) | DRD2SLC6A4HTR1ANAMPTCHRM4 | |
| SCHEMBL8552146 | 0.77 | DRD2 (0.39) | DRD2SLC6A4 | |
| SCHEMBL8547871 | 0.75 | HTR1D (0.43) | DRD2HTR1A | |
| SCHEMBL8552124 | 0.75 | DRD2 (0.43) | DRD2SLC6A4HTR1ANAMPTCHRM4 | |
| SCHEMBL8552460 | 0.74 | DRD2 (0.38) | DRD2SLC6A4RORCHTR6GAK | |
| SCHEMBL8704937 | 0.74 | DRD2 (0.44) | DRD2SLC6A4HTR1ANAMPTCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |