Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | HTR2C | P28335 | 4/20 | 0.33 |
| ▸ | HTR2B | P41595 | 4/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | PNMT | P11086 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30666639 | 1.00 | CES1 (0.34) | CES1HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL30666820 | 0.82 | HTR2A (0.38) | HTR2AHTR2CHTR2B | |
| SCHEMBL30666798 | 0.82 | HTR2A (0.33) | HTR2AHTR2CHTR2B | |
| SCHEMBL5951701 | 0.78 | ACHE (0.50) | CES1HTR2AHTR2CHTR2B | |
| SCHEMBL9329858 | 0.70 | DRD3 (0.36) | HTR2AHTR2CHTR2BADRA2AADRA2B | |
| SCHEMBL8559576 | 0.70 | CES1 (0.34) | CES1HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL7847032 | 0.67 | METAP1 (0.43) | CES1HTR2AHTR2CHTR2B | |
| SCHEMBL11708720 | 0.66 | MAPT (0.39) | HTR2AHTR2CHTR2B | |
| SCHEMBL8552891 | 0.65 | HTR1A (0.38) | CES1HTR2AHTR2C | |
| SCHEMBL1338530 | 0.64 | NOTUM (0.40) | CES1HTR2AHTR2CHTR2BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662971-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1998-05-13 | — | — | EP | disclosed |
| US-5677306-A | ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS | RHONE-POULENC RORER S.A. (FR) | 1997-10-14 | — | — | US | disclosed |
| EP-0662971-A1 | DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007893-A1 | DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1994-04-14 | — | — | WO | disclosed |