SCHEMBL8552891

SCHEMBL8552891

O=C1c2cc(Cl)c(Cl)cc2CC1Br

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 1/20 0.38
DRD2 P14416 1/20 0.38
DRD4 P21917 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
HTR7 P34969 1/20 0.38
DRD3 P35462 1/20 0.38
CES1 P23141 1/20 0.34
ACHE P22303 8/20 0.33
AHR P35869 2/20 0.32
MAPK1 P28482 1/20 0.32
METAP1 P53582 1/20 0.31
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
HSD17B10 Q99714 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11563863 0.81 TSHR (0.39) MAPK1MEN1ALDH1A1MAPTKMT2A
SCHEMBL1694526 0.81 ELANE (0.36) HTR1ADRD2DRD4HTR2AHTR2C
SCHEMBL11658266 0.80 CA2 (0.41) KDM4EMEN1ALDH1A1HPGDKMT2A
SCHEMBL6205822 0.80 L3MBTL1 (0.33) ACHE
SCHEMBL7847032 0.77 METAP1 (0.43) HTR1ADRD2DRD4HTR2AHTR2C
SCHEMBL2370122 0.77 METAP1 (0.53) HTR1ADRD2DRD4HTR2AHTR2C
SCHEMBL30666697 0.77 METAP1 (0.53) HTR1ADRD2DRD4HTR2AHTR2C
SCHEMBL6190911 0.76 ACHE (0.38) ACHEMETAP1KDM4EMEN1ALDH1A1
SCHEMBL30666531 0.76 ACHE (0.38) ACHEMETAP1KDM4EMEN1ALDH1A1
SCHEMBL6975180 0.76 ACHE (0.37) ACHEKDM4EMEN1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020257487-A1 GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE BIOMARIN PHARMACEUTICAL INC. (US) 2020-12-24 WO disclosed
EP-0662971-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE POULENC RORER SA (FR) 1998-05-13 EP disclosed
US-5677306-A ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS RHONE-POULENC RORER S.A. (FR) 1997-10-14 US disclosed
EP-0662971-A1 DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM Aventis Pharma S.A. (FR) 1995-07-19 EP disclosed
WO-1994007893-A1 DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1994-04-14 WO disclosed