Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552252 | 1.00 | NOS2 (0.45) | NOS2 | |
| SCHEMBL8592599 | 0.80 | NOS2 (0.45) | NOS2 | |
| SCHEMBL8592596 | 0.80 | NOS2 (0.45) | NOS2 | |
| SCHEMBL8551346 | 0.72 | NOS1 (0.41) | NOS2 | |
| SCHEMBL8591967 | 0.72 | NOS2 (0.32) | NOS2 | |
| SCHEMBL8591969 | 0.72 | NOS2 (0.32) | NOS2 | |
| SCHEMBL4687009 | 0.72 | NOS2 (0.39) | NOS2 | |
| SCHEMBL8550044 | 0.67 | NOS3 (0.47) | NOS2 | |
| SCHEMBL8550351 | 0.66 | NOS2 (0.38) | NOS2 | |
| SCHEMBL9093089 | 0.66 | NOS2 (0.47) | NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | claimed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | claimed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |