Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 9/20 | 0.53 |
| ▸ | EDNRB | P24530 | 9/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547598 | 0.88 | NPC1 (0.40) | EDNRAEDNRBMAOBNPC1RAB9A | |
| SCHEMBL8553266 | 0.86 | EDNRB (0.56) | EDNRAEDNRB | |
| SCHEMBL8547384 | 0.81 | EDNRB (0.54) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8901587 | 0.79 | EDNRB (0.54) | EDNRAEDNRBMAOBPPARGGABRA1 | |
| SCHEMBL8546850 | 0.78 | KDM4E (0.52) | EDNRAEDNRBNPC1 | |
| SCHEMBL8546890 | 0.74 | EDNRB (0.44) | EDNRAEDNRBNPC1RAB9A | |
| SCHEMBL8553723 | 0.74 | FFAR1 (0.44) | PPARGGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8550354 | 0.72 | ALDH1A1 (0.47) | NPC1RAB9A | |
| SCHEMBL4167529 | 0.71 | MAOB (0.59) | EDNRAEDNRBMAOBNPC1RAB9A | |
| SCHEMBL8551848 | 0.71 | CTSV (0.52) | EDNRAEDNRBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |