Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 8/20 | 0.44 |
| ▸ | PPARD | Q03181 | 7/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.41 |
| ▸ | GABRD | O14764 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.41 |
| ▸ | GABRE | P78334 | 1/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550982 | 0.90 | CTSV (0.44) | FFAR1PPARDPTPN1GABRA1GABRG2 | |
| SCHEMBL8591475 | 0.85 | PTPN1 (0.42) | PTPN1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8553299 | 0.80 | PTPN1 (0.38) | PTPN1GABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL8553319 | 0.78 | PDE4B (0.40) | PTPN1ALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL8697633 | 0.77 | POLB (0.37) | PTPN1MEN1KMT2A | |
| SCHEMBL8697275 | 0.77 | PTPN1 (0.42) | PTPN1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8552298 | 0.74 | EDNRA (0.53) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL8550354 | 0.74 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPTMEN1KMT2A | |
| SCHEMBL8551472 | 0.73 | EDNRB (0.43) | FFAR1PPARDPTPN1 | |
| SCHEMBL8551010 | 0.73 | KDM4E (0.47) | GABRA1GABRG2GABRB3GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |