Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.35 |
| ▸ | TYR | P14679 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775798 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2GAALMNAL3MBTL1KDM4E | |
| SCHEMBL8545068 | 0.71 | CYP17A1 (0.58) | CYP17A1SMN1; SMN2GAAPDE4DLMNA | |
| SCHEMBL8551523 | 0.68 | CYP17A1 (0.47) | CYP17A1SMN1; SMN2GAAPOLBLMNA | |
| SCHEMBL1494092 | 0.67 | GABRA1 (0.46) | LMNASLC6A2TYR | |
| SCHEMBL12475545 | 0.67 | TYR (0.66) | CYP17A1SMN1; SMN2GAAKDM4ECFTR | |
| SCHEMBL8775841 | 0.66 | TBXAS1 (0.56) | SMN1; SMN2GAALMNAL3MBTL1KDM4E | |
| SCHEMBL1849491 | 0.65 | CYP17A1 (0.58) | CYP17A1SMN1; SMN2GAALMNAL3MBTL1 | |
| SCHEMBL30576435 | 0.65 | CYP17A1 (0.58) | CYP17A1SMN1; SMN2GAALMNAL3MBTL1 | |
| SCHEMBL9591930 | 0.65 | SMN1; SMN2 (0.53) | CYP17A1SMN1; SMN2GAALMNAL3MBTL1 | |
| SCHEMBL11737361 | 0.65 | GAA (0.66) | CYP17A1SMN1; SMN2GAALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |