Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7485759 | 0.83 | HTR1D (0.47) | GAAALOX12 | |
| SCHEMBL8548045 | 0.77 | DRD2 (0.34) | GAAALDH1A1DRD2HTR2ADRD3 | |
| SCHEMBL8549309 | 0.77 | UBE2M (0.39) | DRD2SLC6A4 | |
| SCHEMBL8707206 | 0.76 | DRD2 (0.37) | POLBDRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8707209 | 0.76 | DRD2 (0.38) | ALDH1A1DRD2HTR2ADRD3THRB | |
| SCHEMBL8550072 | 0.75 | MAPT (0.44) | POLBGAAMAPTALDH1A1DRD2 | |
| SCHEMBL8548067 | 0.74 | KMT2A (0.41) | POLBGAAMAPTALDH1A1DRD2 | |
| SCHEMBL8548353 | 0.73 | UBE2M (0.40) | DRD2HTR2ADRD3 | |
| SCHEMBL8709640 | 0.72 | DRD2 (0.53) | DRD2HTR2ADRD3SLC6A4 | |
| SCHEMBL8548389 | 0.72 | DRD2 (0.39) | DRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |