Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552602 | 0.79 | KDM4E (0.35) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL5963617 | 0.72 | KLK7 (0.36) | MAPTUSP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL7979086 | 0.72 | KLK7 (0.36) | MAPTUSP2SMN1; SMN2CHRM2CHRM1 | |
| SCHEMBL5963373 | 0.69 | EPHX1 (0.37) | KDM4EMAPTCHRM2CHRM1CHRM3 | |
| SCHEMBL15317901 | 0.63 | NFKB1 (0.39) | MAPTTHRBCHRM2CHRM1CHRM3 | |
| SCHEMBL31622247 | 0.62 | RECQL (0.54) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL959713 | 0.62 | NR1H2 (0.43) | KDM4EMAPTTHRBUSP2SMN1; SMN2 | |
| SCHEMBL8553981 | 0.62 | ELANE (0.36) | CHRM2CHRM1CHRM3KLK7 | |
| SCHEMBL9093094 | 0.62 | ELANE (0.36) | CHRM2CHRM1CHRM3KLK7 | |
| SCHEMBL8593795 | 0.62 | ELANE (0.36) | CHRM2CHRM1CHRM3KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |