Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552400 | 0.81 | CYP1A2 (0.38) | LMNAHTTTSHRALDH1A1PGR | |
| SCHEMBL18940526 | 0.79 | LMNA (0.32) | LMNAHTTTSHRHSD17B10MAPT | |
| SCHEMBL4905925 | 0.77 | CA1 (0.44) | LMNAHTTTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL5704313 | 0.77 | MTNR1A (0.40) | LMNAHTTTSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL16167281 | 0.71 | TSHR (0.36) | LMNAHTTTSHRHSD17B10ALDH1A1 | |
| SCHEMBL28131493 | 0.68 | CA1 (0.45) | LMNAHTTPPARGPSIP1 | |
| SCHEMBL5704304 | 0.68 | SMN1; SMN2 (0.42) | LMNAALDH1A1SMN1; SMN2MAPTMTNR1A | |
| SCHEMBL17706031 | 0.68 | TDP1 (0.39) | LMNATSHRHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL6923665 | 0.68 | CA1 (0.54) | LMNAPPARG | |
| SCHEMBL28078111 | 0.67 | CA1 (0.44) | LMNAPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |