Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | GRK5 | P34947 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | NEK2 | P51955 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558058 | 0.89 | CHEK1 (0.41) | PDE9AADORA3CHEK1DAPK3PRKD3 | |
| SCHEMBL8557555 | 0.82 | PDE5A (0.45) | PDE9AADORA3CHEK1DAPK3PRKD3 | |
| SCHEMBL8559120 | 0.82 | ADORA3 (0.50) | PDE9AADORA3GRIN2DGRIN3BGRIA1 | |
| SCHEMBL8557905 | 0.81 | GRIN2D (0.43) | ADORA3CHEK1DAPK3PRKD3MET | |
| SCHEMBL8558977 | 0.80 | PDE5A (0.38) | PDE9AADORA3CHEK1DAPK3PRKD3 | |
| SCHEMBL8557418 | 0.79 | PDE5A (0.49) | PDE9AADORA3 | |
| SCHEMBL8553821 | 0.79 | POLB (0.49) | PDE9AADORA3 | |
| SCHEMBL8557421 | 0.78 | EGLN1 (0.38) | PDE9AADORA3CHEK1DAPK3PRKD3 | |
| SCHEMBL8553483 | 0.78 | CHEK1 (0.43) | PARP1ADORA3CHEK1DAPK3PRKD3 | |
| SCHEMBL8554013 | 0.78 | ADORA3 (0.46) | ADORA3CHEK1DAPK3PRKD3MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |