Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.63 |
| ▸ | ADRB3 | P13945 | 5/20 | 0.63 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.63 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ATF4 | P18848 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25053044 | 0.87 | ADRB1 (0.69) | CYP3A4CYP2D6ADRB1ADRB3ADRB2 | |
| SCHEMBL20883370 | 0.77 | TSHR (0.69) | CYP3A4CYP2D6TSHRLMNAMEN1 | |
| SCHEMBL20883491 | 0.76 | LMNA (0.64) | CYP3A4CYP2D6ADRB1ADRB3ADRB2 | |
| SCHEMBL8553914 | 0.75 | USP2 (0.58) | CYP2D6HTR2ALMNAMEN1KMT2A | |
| SCHEMBL22545051 | 0.75 | ADRB1 (0.55) | CYP3A4CYP2D6ADRB1ADRB3ADRB2 | |
| SCHEMBL7808692 | 0.75 | TSHR (0.75) | CYP2D6TSHRMEN1KMT2AMAPT | |
| SCHEMBL22640024 | 0.75 | MEN1 (0.70) | ADRB2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL22640079 | 0.75 | MEN1 (0.70) | ADRB2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL20877004 | 0.75 | ADRB3 (0.60) | CYP3A4CYP2D6ADRB1ADRB3ADRB2 | |
| SCHEMBL20854550 | 0.74 | KCNH2 (0.62) | TSHRLMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0842174-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING MYOCARDIAL ISCHAEMIA | PIERRE FABRE MEDICAMENT (FR) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997005134-A1 | HETEROCYCLIC COMPOUNDS FOR TREATING MYOCARDIAL ISCHAEMIA | PIERRE FABRE MEDICAMENT (FR) | 1997-02-13 | — | — | WO | disclosed |