Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9126942 | 0.71 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL16430485 | 0.66 | DRD2 (0.50) | — | |
| SCHEMBL17078101 | 0.66 | DRD2 (0.50) | — | |
| SCHEMBL9127152 | 0.65 | LMNA (0.33) | LMNAGAAALDH1A1 | |
| SCHEMBL27524882 | 0.62 | — | — | |
| SCHEMBL15348948 | 0.62 | F2RL3 (0.40) | LMNAALDH1A1 | |
| SCHEMBL26685345 | 0.59 | CNR2 (0.34) | — | |
| SCHEMBL8552745 | 0.58 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL9126495 | 0.58 | ALOX5 (0.33) | — | |
| SCHEMBL5148878 | 0.57 | SMN1; SMN2 (0.33) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| US-5478843-A | Administering as inhibitors of the enzyme 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1995004055-A1 | THIAZOLE DERIVATIVES AS LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |
| EP-0636624-A1 | Thiazole derivatives as lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |