Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8594128 | 0.80 | SMN1; SMN2 (0.55) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8552717 | 0.78 | LMNA (0.47) | LMNAGAAHTTCHRM4SMN1; SMN2 | |
| SCHEMBL8552715 | 0.78 | LMNA (0.47) | LMNAGAAHTTCHRM4SMN1; SMN2 | |
| SCHEMBL28978045 | 0.78 | HTT (0.68) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8549063 | 0.78 | TSHR (0.53) | GAAHTTSMN1; SMN2ALDH1A1HPGD | |
| Bromide SCHEMBL8592755 | 0.77 | LMNA (0.37) | LMNAGAACHRM4KDM4EALDH1A1 | |
| SCHEMBL8553852 | 0.74 | HTT (0.45) | LMNAHTTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7281136 | 0.72 | HTT (0.65) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL7282881 | 0.71 | SMN1; SMN2 (0.60) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL13274303 | 0.71 | HTT (0.69) | HTTSMN1; SMN2NPC1RAB9AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |