Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8553025 | 0.81 | MAPT (0.49) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL8554224 | 0.72 | MAPT (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8554053 | 0.71 | MAPT (0.51) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8592052 | 0.70 | MAPT (0.50) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| Hydrochloric Acid SCHEMBL8593690 | 0.70 | CXCR1 (0.44) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL8553387 | 0.70 | POLB (0.50) | MAPTKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL17385038 | 0.70 | ALDH1A1 (0.48) | MAPTKDM4EPIN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8326762 | 0.69 | MAPT (0.64) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 | |
| Bromide SCHEMBL8551319 | 0.69 | POLB (0.44) | KCNH2ALDH1A1MEN1KMT2AHPGD | |
| Hydrochloric Acid SCHEMBL8327375 | 0.69 | MAPT (0.63) | MAPTKDM4EALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |