Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | ACE | P12821 | 3/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9304813 | 0.80 | NOTUM (0.46) | ALDH1A1NOTUMMTNR1AACEKDM4E | |
| SCHEMBL11622288 | 0.78 | NOTUM (0.47) | ALDH1A1NOTUMMTNR1AKDM4EGAA | |
| SCHEMBL5740568 | 0.72 | SMN1; SMN2 (0.49) | ALDH1A1NOTUMACEABCB11AGTR2 | |
| SCHEMBL11624878 | 0.70 | NOTUM (0.43) | ALDH1A1NOTUMKDM4ESMN1; SMN2GAA | |
| SCHEMBL2566122 | 0.69 | MTNR1A (0.48) | ALDH1A1NOTUMMTNR1ASMN1; SMN2GAA | |
| SCHEMBL7831498 | 0.69 | POLB (0.56) | ALDH1A1NOTUMKDM4ESMN1; SMN2GAA | |
| SCHEMBL11756352 | 0.68 | MTNR1A (0.48) | ALDH1A1NOTUMMTNR1AACEKDM4E | |
| SCHEMBL433888 | 0.68 | MTNR1A (0.54) | ALDH1A1NOTUMMTNR1AACEKDM4E | |
| SCHEMBL7867727 | 0.67 | CYP4F2 (0.45) | ALDH1A1TDP1KDM4EGAAKMT2A | |
| SCHEMBL5695475 | 0.67 | CYP4F2 (0.45) | ALDH1A1TDP1KDM4EGAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |