Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 11/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 5/20 | 0.37 |
| ▸ | RAD52 | P43351 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PHGDH | O43175 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552755 | 0.86 | KDM4E (0.43) | KDM4EMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL7147572 | 0.86 | MAPT (0.43) | KDM4EMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL8548267 | 0.81 | KDM4E (0.41) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8553478 | 0.77 | MAPT (0.37) | MAPTALDH1A1MEN1KMT2AHTT | |
| SCHEMBL8554008 | 0.75 | BRAF (0.30) | — | |
| SCHEMBL8547854 | 0.72 | SMN1; SMN2 (0.45) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8547927 | 0.69 | ROCK1 (0.37) | KDM4EMAPTALDH1A1GAARAD52 | |
| SCHEMBL8192418 | 0.69 | HSP90AA1 (0.38) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL8552127 | 0.68 | KDM4E (0.39) | KDM4EMAPTALDH1A1RAB9AKMT2A | |
| SCHEMBL8550370 | 0.66 | KDM4E (0.41) | KDM4EMAPTALDH1A1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |