Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 9/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8071527 | 0.80 | CYP3A4 (0.49) | LRRK2KCNA5 | |
| SCHEMBL8186428 | 0.80 | CYP3A4 (0.49) | LRRK2KCNA5 | |
| SCHEMBL8553152 | 0.80 | KCNA5 (0.47) | LRRK2HSD17B10KMT2AKCNA5ADRB3 | |
| SCHEMBL7772046 | 0.78 | SLC6A4 (0.42) | LRRK2KMT2AKCNA5 | |
| SCHEMBL7773934 | 0.78 | SLC6A4 (0.42) | LRRK2KMT2AKCNA5 | |
| SCHEMBL8557113 | 0.74 | CYP51A1 (0.47) | KMT2AADRB3ADRB1PDE4DMKNK1 | |
| SCHEMBL8555243 | 0.71 | AKR1C3 (0.41) | KCNA5ADRB3ADRB1MKNK1MKNK2 | |
| SCHEMBL8555638 | 0.71 | SUCNR1 (0.43) | KMT2AKCNA5ADRB3ADRB1 | |
| SCHEMBL8554047 | 0.71 | SLC6A2 (0.51) | KCNA5 | |
| SCHEMBL8550969 | 0.70 | EPHX1 (0.46) | KCNA5ADRB3ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |