Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.44 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096479 | 0.83 | HSD11B1 (0.55) | OPRM1OPRK1OPRL1SMN1; SMN2NPC1 | |
| SCHEMBL27573221 | 0.76 | AVPR1A (0.60) | OPRM1OPRK1OPRL1AVPR1AKDM4E | |
| SCHEMBL4676088 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9ABTKJAK2 | |
| SCHEMBL29087407 | 0.75 | SMN1; SMN2 (0.56) | OPRL1SMN1; SMN2NPC1RAB9AJAK2 | |
| SCHEMBL4676594 | 0.75 | SLC6A4 (0.53) | OPRM1OPRK1OPRL1SMN1; SMN2NPC1 | |
| SCHEMBL4771971 | 0.74 | AVPR1A (0.50) | AVPR1AJAK2JAK1TYK2JAK3 | |
| SCHEMBL8103890 | 0.74 | SLC6A4 (0.53) | OPRM1OPRK1OPRL1AVPR1A | |
| SCHEMBL1093313 | 0.73 | PDE4B (0.57) | SMN1; SMN2NPC1RAB9ATRPC3TRPC7 | |
| SCHEMBL16801526 | 0.73 | KDM4E (0.69) | OPRM1OPRK1OPRL1AVPR1AKDM4E | |
| SCHEMBL6603778 | 0.73 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1RAB9AJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |