Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.55 |
| ▸ | HTR1A | P08908 | 3/20 | 0.49 |
| ▸ | HTR7 | P34969 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.48 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.48 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671603 | 0.83 | HSD11B1 (0.56) | HSD11B1HTR1AOPRM1OPRK1OPRL1 | |
| SCHEMBL8553210 | 0.83 | OPRM1 (0.51) | OPRM1OPRK1OPRL1ALDH1A1BTK | |
| SCHEMBL4676594 | 0.80 | SLC6A4 (0.53) | OPRM1OPRK1OPRL1SLC6A4NPC1 | |
| SCHEMBL4671070 | 0.80 | MMP1 (0.49) | HSD11B1HTR1AHTR7OPRM1OPRK1 | |
| SCHEMBL4676088 | 0.79 | SMN1; SMN2 (0.47) | HTR1ABTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7444873 | 0.77 | HSD11B1 (0.56) | HSD11B1HTR1AHTR7OPRM1OPRK1 | |
| SCHEMBL5340537 | 0.76 | HSD11B1 (0.68) | HSD11B1HTR1AOPRM1OPRK1OPRL1 | |
| SCHEMBL4671108 | 0.76 | JAK2 (0.45) | HSD11B1OPRM1OPRK1OPRL1HTR1D | |
| SCHEMBL10922885 | 0.76 | HSD11B1 (0.66) | HSD11B1HTR1AHTR7OPRM1OPRK1 | |
| SCHEMBL7316014 | 0.76 | HSD11B1 (0.54) | HSD11B1HTR1AOPRM1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6143744-A | Sulfamide-metalloprotease inhibitors | SYNTEX (U.S.A.) INC. (US) | 2000-11-07 | — | — | US | disclosed |
| US-5998412-A | ANTIARTHRITIC AGENTS; OSTEOPOROSIS | SYNTEX (U.S.A.) INC. (US) | 1999-12-07 | — | — | US | disclosed |