Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.48 |
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.48 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.91 |
| ▸ | DRD4 | P21917 | 1/20 | 0.91 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7516300 | 0.95 | HTR2A (1.00) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL6907364 | 0.95 | HTR2A (1.00) | HTR2ADRD4DRD2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8552262 | 0.95 | HTR2A (0.98) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL8552863 | 0.89 | HTR2A (0.87) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL3726273 | 0.84 | HTR2A (0.79) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL13041313 | 0.82 | DRD4 (0.75) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL8552184 | 0.72 | DRD4 (0.61) | HTR2ADRD4DRD2MEN1KMT2A | |
| SCHEMBL8558550 | 0.71 | HTR2A (0.59) | HTR2ADRD4DRD2 | |
| SCHEMBL8556407 | 0.71 | DRD4 (0.59) | HTR2ADRD4MEN1KMT2A | |
| SCHEMBL8553513 | 0.71 | HTR2A (0.59) | HTR2ADRD4DRD2HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0816362-A1 | THIAZOLE DERIVATIVES | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1998-01-07 | — | — | EP | disclosed |