Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8621833 | 0.93 | TRPV1 (0.41) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8554387 | 0.87 | TRPV1 (0.46) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8553467 | 0.86 | LMNA (0.48) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL27501117 | 0.85 | ASAH1 (0.45) | KMT2AEPHX2 | |
| SCHEMBL8555006 | 0.85 | TRPV1 (0.46) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8553418 | 0.84 | TRPV1 (0.43) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8549732 | 0.84 | TRPV1 (0.45) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8552106 | 0.83 | TRPV1 (0.50) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8555180 | 0.83 | TRPV1 (0.42) | TRPV1KMT2AALDH1A1HPGDLMNA | |
| SCHEMBL8623812 | 0.83 | L3MBTL1 (0.39) | KMT2AALDH1A1LMNAGAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |