Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8553648 | 0.99 | OPRK1 (0.61) | OPRK1KMT2AALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL8552933 | 0.87 | SIGMAR1 (0.60) | KMT2ASIGMAR1MEN1SMN1; SMN2ACHE | |
| SCHEMBL8553137 | 0.87 | SIGMAR1 (0.60) | SIGMAR1MCHR1SMN1; SMN2ACHE | |
| Hydrochloric Acid SCHEMBL8554807 | 0.86 | MEN1 (0.59) | KMT2ASIGMAR1MEN1SMN1; SMN2ACHE | |
| SCHEMBL8551618 | 0.86 | OPRK1 (0.56) | OPRK1KMT2AALDH1A1KDM4EMEN1 | |
| Hydrochloric Acid SCHEMBL8553721 | 0.86 | SIGMAR1 (0.58) | KMT2ASIGMAR1MCHR1MEN1SMN1; SMN2 | |
| SCHEMBL8550490 | 0.85 | BCHE (0.65) | OPRK1KMT2AMEN1ACHE | |
| Hydrochloric Acid SCHEMBL8551962 | 0.85 | OPRK1 (0.55) | OPRK1KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL8551006 | 0.85 | BCHE (0.59) | OPRK1KMT2AALDH1A1KDM4ESIGMAR1 | |
| Hydrochloric Acid SCHEMBL8556315 | 0.84 | MEN1 (0.65) | OPRK1KMT2AMEN1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | claimed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |