Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 6/20 | 0.38 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6606838 | 0.83 | AGTR1 (0.53) | MAP2K1ALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL8944455 | 0.83 | AGTR1 (0.43) | ALDH1A1AGTR1AGTR2 | |
| SCHEMBL8550701 | 0.83 | ALDH1A1 (0.41) | MAP2K1ALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL6611120 | 0.81 | AGTR1 (0.55) | ALDH1A1AGTR1AGTR2SMN1; SMN2 | |
| SCHEMBL8548646 | 0.80 | AGTR1 (0.39) | ALDH1A1AGTR1AGTR2 | |
| SCHEMBL6608915 | 0.79 | AGTR1 (0.42) | ALDH1A1KDM4EL3MBTL1TDP1LMNA | |
| SCHEMBL8550700 | 0.78 | KDM4E (0.49) | MAP2K1ALDH1A1KDM4EL3MBTL1TDP1 | |
| SCHEMBL9296520 | 0.77 | AGTR1 (0.46) | AGTR1AGTR2 | |
| SCHEMBL6606990 | 0.77 | AGTR1 (0.57) | AGTR1AGTR2 | |
| SCHEMBL9409382 | 0.76 | KDM4E (0.39) | ALDH1A1KDM4EL3MBTL1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |