Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2426429 | 0.80 | ALDH1A1 (0.40) | ALDH1A1CA2LMNAKDM4EHTT | |
| SCHEMBL12521990 | 0.80 | MAPT (0.42) | ALDH1A1LMNAL3MBTL1KDM4EHTR4 | |
| SCHEMBL2387235 | 0.75 | L3MBTL1 (0.41) | ALDH1A1LMNAL3MBTL1KDM4EHTR4 | |
| SCHEMBL12449176 | 0.75 | ALDH1A1 (0.46) | ALDH1A1CYP2C9LMNAL3MBTL1KDM4E | |
| SCHEMBL8553638 | 0.73 | PAOX (0.39) | ALDH1A1LMNAL3MBTL1KDM4EPAOX | |
| SCHEMBL2446798 | 0.73 | L3MBTL1 (0.42) | L3MBTL1KDM4EHTR4GAAPKM | |
| SCHEMBL17039352 | 0.72 | L3MBTL1 (0.45) | ALDH1A1L3MBTL1KDM4EMAPT | |
| SCHEMBL17033124 | 0.72 | L3MBTL1 (0.41) | L3MBTL1KDM4EHTR4GAAPKM | |
| SCHEMBL31061327 | 0.72 | L3MBTL1 (0.41) | ALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL1667133 | 0.72 | L3MBTL1 (0.45) | ALDH1A1LMNAL3MBTL1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562440-B1 | Imidazopyridazines as antiasthmatics | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-12-23 | — | — | EP | disclosed |
| US-5491145-A | ANTIASTHMA, ANTI-PLATELET ACTIVATING FACTOR BRONCHOCONSTRICTION-INHIBITING AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0562440-A1 | Imidazopyridazines as antiasthmatics | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-29 | — | — | EP | disclosed |