Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846467 | 0.88 | ERN1 (0.40) | ERN1ALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL8125146 | 0.88 | ERN1 (0.50) | ERN1ALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL9706985 | 0.85 | ALDH1A1 (0.37) | ALDH1A1POLBRAB9ASMN1; SMN2HTT | |
| SCHEMBL8553675 | 0.80 | ERN1 (0.38) | ERN1ALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL10718466 | 0.77 | ALDH1A1 (0.44) | ERN1ALDH1A1MAPTLMNAKMT2A | |
| SCHEMBL11024806 | 0.76 | KMT2A (0.38) | ALDH1A1POLBRAB9ASMN1; SMN2HTT | |
| SCHEMBL11029585 | 0.76 | CYP1A2 (0.44) | ALDH1A1POLBSMN1; SMN2MAPTLMNA | |
| SCHEMBL10377296 | 0.75 | GLO1 (0.39) | ERN1ALDH1A1SMN1; SMN2HTTGLO1 | |
| SCHEMBL11028650 | 0.74 | HTT (0.42) | ALDH1A1SMN1; SMN2HTTNPC1MAPT | |
| SCHEMBL11026774 | 0.73 | ALDH1A1 (0.39) | ALDH1A1POLBRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529100-B1 | INDOLINOSPIROBENZOPYRAN DERIVATIVE | OTSUKA KAGAKU KK (JP) | 1998-11-11 | — | — | EP | disclosed |
| EP-0530369-B1 | CRYSTAL COMPRISING INDOLINOSPIROBENZOTHIOPYRAN DERIVATIVE AND RING-OPENING ISOMER THEREOF | OTSUKA KAGAKU KK (JP) | 1997-02-05 | — | — | EP | disclosed |
| EP-0466938-B1 | HIGH-MOLECULAR SPIROPYRAN COMPOUND | OTSUKA KAGAKU KK (JP) | 1996-12-27 | — | — | EP | disclosed |
| EP-0411157-B1 | SPIROPYRAN COMPOUNDS | OTSUKA KAGAKU KK (JP) | 1996-05-22 | — | — | EP | disclosed |
| US-5403702-A | Crystals consisting of an indolinospirobenzopyran derivative | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1995-04-04 | — | — | US | disclosed |
| US-5320784-A | Crystal comprising an indolinospirobenzothiopyran derivative and its ring opened isomer | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1994-06-14 | — | — | US | disclosed |
| US-5252742-A | Spiropyran compounds | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-10-12 | — | — | US | disclosed |
| US-5241027-A | MACROMOLECULAR SPIROPYRAN COMPOUNDS | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-08-31 | — | — | US | disclosed |
| EP-0530369-A1 | CRYSTAL COMPRISING INDOLINOSPIROBENZOTHIOPYRAN DERIVATIVE AND RING-OPENING ISOMER THEREOF | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-03-10 | — | — | EP | disclosed |
| EP-0529100-A1 | INDOLINOSPIROBENZOPYRAN DERIVATIVE | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1993-03-03 | — | — | EP | disclosed |
| EP-0466938-A1 | HIGH-MOLECULAR SPIROPYRAN COMPOUND | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1992-01-22 | — | — | EP | disclosed |
| EP-0411157-A1 | SPIROPYRAN COMPOUNDS | OTSUKA KAGAKU KABUSHIKI KAISHA (JP) | 1991-02-06 | — | — | EP | disclosed |