Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553759 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2SHMT1SHMT2 | |
| SCHEMBL8557083 | 0.86 | GAA (0.46) | ALDH1A1MEN1KMT2APTGS2GAA | |
| SCHEMBL8656928 | 0.86 | GAA (0.46) | ALDH1A1MEN1KMT2APTGS2GAA | |
| SCHEMBL8556995 | 0.86 | SDCBP (0.47) | ALDH1A1HSD17B10PSMB5PSMB8CA1 | |
| SCHEMBL8556999 | 0.86 | SDCBP (0.47) | ALDH1A1HSD17B10PSMB5PSMB8CA1 | |
| SCHEMBL8556439 | 0.85 | ALDH1A1 (0.54) | KDM4EALDH1A1CA1CA2 | |
| SCHEMBL8556435 | 0.85 | ALDH1A1 (0.54) | KDM4EALDH1A1CA1CA2 | |
| SCHEMBL8556273 | 0.84 | CA2 (0.46) | KDM4EALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL8556276 | 0.84 | CA2 (0.46) | KDM4EALDH1A1MEN1KMT2ACA1 | |
| SCHEMBL4426812 | 0.83 | PRSS1 (0.48) | KDM4EALDH1A1SMN1; SMN2SHMT1SHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847211-A | Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| US-5622917-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |