SCHEMBL8553874

SCHEMBL8553874

O=C(OC1CCN(Cc2ccccc2)CC1)c1ccc(Br)cc1[N+](=O)[O-]

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.48
SIGMAR1 Q99720 2/20 0.48
MAPK1 P28482 3/20 0.47
KDM4E B2RXH2 1/20 0.47
ALDH1A1 P00352 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
PGR P06401 1/20 0.46
CHRM2 P08172 1/20 0.46
ABCB1 P08183 1/20 0.46
HTR1A P08908 1/20 0.46
ADRA2A P08913 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
CHRM1 P11229 1/20 0.46
DRD1 P21728 1/20 0.46
TBXA2R P21731 1/20 0.46
SLC6A2 P23975 1/20 0.46
SLC6A4 P31645 1/20 0.46
ADRA1A P35348 1/20 0.46
OPRM1 P35372 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8551803 0.99 BCHE (0.47) BCHESIGMAR1MAPK1KDM4EALDH1A1
SCHEMBL8550623 0.88 BCHE (0.48) BCHESIGMAR1MAPK1PGRCHRM2
SCHEMBL8552219 0.87 SIGMAR1 (0.55) BCHESIGMAR1MAPK1
Hydrochloric Acid SCHEMBL8551753 0.87 BCHE (0.47) BCHESIGMAR1MAPK1PGRCHRM2
Hydrochloric Acid SCHEMBL8555949 0.86 SIGMAR1 (0.54) BCHESIGMAR1MAPK1
SCHEMBL8550733 0.85 MAPK1 (0.61) BCHESIGMAR1MAPK1NPSR1KCNH2
Hydrochloric Acid SCHEMBL8554803 0.84 MAPK1 (0.60) BCHESIGMAR1MAPK1NPSR1FAAH
SCHEMBL8551172 0.83 BCHE (0.52) BCHESIGMAR1SMN1; SMN2CHRM2DRD3
SCHEMBL8553705 0.83 BCHE (0.52) BCHESIGMAR1MAPK1ALDH1A1CHRM2
Hydrochloric Acid SCHEMBL8554127 0.82 BCHE (0.51) BCHESIGMAR1SMN1; SMN2CHRM2DRD3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US claimed
CN-1084329-C Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 2002-05-08 CN disclosed
EP-0871613-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F. HOFFMANN-LA ROCHE AG (CH) 1998-10-21 EP disclosed
CN-1183768-A Benzyl piepridine derivs as pharmaceutical agents HOFFMANN LA ROCHE (CH) 1998-06-03 CN disclosed
US-5753679-A SCIZOPHRENIA HOFFMANN-LA ROCHE INC. (US) 1998-05-19 US disclosed
WO-1996035666-A1 BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS F.HOFFMANN-LA ROCHE AG (CH) 1996-11-14 WO disclosed