SCHEMBL8553879

SCHEMBL8553879

[NH]c1nc(N)[nH]c(=O)c1NC=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 1/20 0.39
CDK1 P06493 1/20 0.39
CDK4 P11802 1/20 0.39
CDK2 P24941 1/20 0.39
PNP P00491 2/20 0.38
NPSR1 Q6W5P4 1/20 0.37
DYRK1A Q13627 1/20 0.36
KDM4E B2RXH2 1/20 0.35
LMNA P02545 1/20 0.35
GLA P06280 1/20 0.35
PMP22 Q01453 1/20 0.35
HSD17B10 Q99714 1/20 0.35
MITF O75030 1/20 0.34
TP53 P04637 1/20 0.34
THRB P10828 1/20 0.34
ALOX15 P16050 1/20 0.34
HBB P68871 1/20 0.34
HIF1A Q16665 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7914803 0.83 ALDH1A1 (0.56) ALDH1A1CYP2C19MAPTCDK1CDK4
SCHEMBL23710109 0.80 ALDH1A1 (0.57) ALDH1A1CYP2C19MAPTCDK1CDK4
SCHEMBL4570273 0.80 ALDH1A1 (0.54) ALDH1A1CYP2C19MAPTCDK1CDK4
SCHEMBL27099546 0.79 ALDH1A1 (0.64) ALDH1A1CYP2C19MAPTCDK1CDK4
SCHEMBL17844454 0.72 ALDH1A1 (0.49) ALDH1A1CYP2C19MAPTCDK1CDK4
SCHEMBL27903732 0.70 ALDH1A1 (0.53) ALDH1A1CYP2C19MAPTKDM4E
SCHEMBL9513541 0.67 GAA (0.44) ALDH1A1CYP2C19MAPTPNP
SCHEMBL23710118 0.65 ALDH1A1 (0.47) ALDH1A1CYP2C19
SCHEMBL23710120 0.65 ALDH1A1 (0.44) ALDH1A1CYP2C19
SCHEMBL23710116 0.65 ALDH1A1 (0.47) ALDH1A1CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0719265-B1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT ENERGIE ATOMIQUE (FR) 1998-12-02 EP claimed
US-5721341-A Derivatives of nucleosides, processes for the production of these derivatives of nucleosides and specific polyclonal and monoclonal antibodies of these derivatives COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1998-02-24 US claimed
EP-0719265-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1996-07-03 EP claimed
WO-1995007907-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1995-03-23 WO claimed
EP-0719265-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1996-07-03 EP disclosed
WO-1995007907-A1 NUCLEOSIDE DERIVATIVES, METHODS FOR THE MANUFACTURE THEREOF AND SPECIFIC POLYCLONAL AND MONOCLONAL ANTIBODIES OF SAID DERIVATIVES COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) 1995-03-23 WO disclosed