Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551826 | 0.89 | FFAR4 (0.44) | HDAC6FFAR1FFAR4CYP3A4KCNH2 | |
| SCHEMBL8604570 | 0.89 | HDAC6 (0.38) | HDAC6FFAR1FFAR4CYP3A4KCNH2 | |
| SCHEMBL9091116 | 0.87 | TSHR (0.43) | HDAC6HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL9089363 | 0.86 | NPSR1 (0.42) | HDAC6THRATHRBALDH1A1MEN1 | |
| SCHEMBL8824429 | 0.83 | THRA (0.39) | HDAC6THRATHRBHDAC3NCOR1 | |
| SCHEMBL9089935 | 0.81 | HDAC6 (0.39) | HDAC6HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL8557288 | 0.81 | HDAC6 (0.39) | HDAC6HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL9089670 | 0.81 | RAB9A (0.40) | HDAC6HDAC3NCOR1HDAC1HDAC2 | |
| SCHEMBL8553780 | 0.81 | NPC1 (0.36) | HDAC6FFAR1CYP3A4NPC1NFKB1 | |
| SCHEMBL8661865 | 0.80 | NPC1 (0.34) | HDAC6FFAR1CYP3A4TP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846986-A | Therapeutic phenoxyalkylazoles and phenoxyalkylazines | SANOFI (FR) | 1998-12-08 | — | — | US | disclosed |
| US-5721261-A | TREATING PICORNAVIRUS INFECTIONS | SANOFI PHARMACEUTICALS, INC. (US) | 1998-02-24 | — | — | US | disclosed |
| US-5552420-A | TREATING PICORNAVIRAL INFECTIONS | STERLING WINTHROP INC. (US) | 1996-09-03 | — | — | US | disclosed |
| WO-1995031452-A1 | THERAPEUTIC PHENOXYALKYLAZOLES AND PHENOXYALKYLAZINES | SANOFI WINTHROP, INC. (US) | 1995-11-23 | — | — | WO | disclosed |