Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 18/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9089935 | 0.83 | HDAC6 (0.39) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL9091116 | 0.82 | TSHR (0.43) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL8604570 | 0.82 | HDAC6 (0.38) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL8551826 | 0.82 | FFAR4 (0.44) | HDAC6TP53 | |
| SCHEMBL8553882 | 0.81 | HDAC6 (0.37) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL9089363 | 0.79 | NPSR1 (0.42) | HDAC6BRD4 | |
| SCHEMBL8824429 | 0.79 | THRA (0.39) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL9089670 | 0.75 | RAB9A (0.40) | HDAC6HDAC2HDAC3NCOR1HDAC1 | |
| SCHEMBL8553780 | 0.75 | NPC1 (0.36) | HDAC6 | |
| SCHEMBL8555548 | 0.74 | LMNA (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846986-A | Therapeutic phenoxyalkylazoles and phenoxyalkylazines | SANOFI (FR) | 1998-12-08 | — | — | US | disclosed |
| US-5721261-A | TREATING PICORNAVIRUS INFECTIONS | SANOFI PHARMACEUTICALS, INC. (US) | 1998-02-24 | — | — | US | disclosed |