SCHEMBL8553896

SCHEMBL8553896

Clc1nn2ccnc2c2c1CCCC2

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14554102 0.78 HPGD (0.32) HPGDSMN1; SMN2
SCHEMBL11106582 0.76 HTR6 (0.37)
SCHEMBL10916033 0.75 SMPD3 (0.35)
SCHEMBL10917458 0.75 SMPD3 (0.36)
SCHEMBL11199795 0.73 SYK (0.36) HPGD
SCHEMBL10963152 0.73 SYK (0.36) HPGD
SCHEMBL10921230 0.71 HTT (0.49) HPGD
SCHEMBL3021418 0.71 HPGD (0.33) HPGDSMN1; SMN2
SCHEMBL10919711 0.70 HTT (0.42) HPGDSMN1; SMN2
SCHEMBL10918062 0.68 KMT2A (0.39) HPGDSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0562440-B1 Imidazopyridazines as antiasthmatics TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-12-23 EP disclosed
US-5491145-A ANTIASTHMA, ANTI-PLATELET ACTIVATING FACTOR BRONCHOCONSTRICTION-INHIBITING AGENTS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-02-13 US disclosed
EP-0562440-A1 Imidazopyridazines as antiasthmatics TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1993-09-29 EP disclosed
EP-0099081-B1 6-SUBSTITUTED TETRAHYDROIMIDAZO(2,1-A)-PHTHALAZINES THE DOW CHEMICAL COMPANY (US) 1986-09-03 EP disclosed
EP-0099081-A2 6-Substituted tetrahydroimidazo(2,1-a)-phthalazines THE DOW CHEMICAL COMPANY (US) 1984-01-25 EP disclosed
US-4391807-A 6-Substituted tetrahydroimidazo[2,1-a]phthalazines and use as bronchodilators THE DOW CHEMICAL COMPANY (US) 1983-07-05 US disclosed