Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | F13A1 | P00488 | 1/20 | 0.40 |
| ▸ | TGM2 | P21980 | 1/20 | 0.40 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6803279 | 1.00 | SIGMAR1 (0.45) | SIGMAR1NPC1RAB9ASMN1; SMN2PLK1 | |
| SCHEMBL6801926 | 0.94 | SIGMAR1 (0.48) | SIGMAR1NPC1RAB9ASMN1; SMN2PLK1 | |
| SCHEMBL6800799 | 0.89 | SIGMAR1 (0.49) | SIGMAR1S1PR2S1PR1THRATHRB | |
| SCHEMBL27347413 | 0.86 | LOXL2 (0.38) | SIGMAR1 | |
| SCHEMBL6796677 | 0.86 | HPGD (0.40) | SIGMAR1SMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3059803 | 0.83 | SIGMAR1 (0.51) | SIGMAR1NPC1RAB9APOLB | |
| SCHEMBL6802210 | 0.78 | AKR1C3 (0.42) | SIGMAR1 | |
| SCHEMBL6803232 | 0.78 | ALDH1A1 (0.49) | NPC1RAB9ASMN1; SMN2PLK1ALDH1A1 | |
| SCHEMBL6802810 | 0.77 | HTR2A (0.46) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6807729 | 0.77 | S1PR1 (0.51) | NPC1RAB9ASMN1; SMN2PLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854863-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |
| WO-1997003951-A1 | ESTERS AND AMIDES AS PLA2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-02-06 | — | — | WO | disclosed |