Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | ESRRG | P62508 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551502 | 0.85 | HTR1F (0.46) | MAPTKDM4ENPC1GALR3RAB9A | |
| Oxalic Acid SCHEMBL8548077 | 0.82 | EGFR (0.41) | EGFRERBB2MAPTKDM4ENPC1 | |
| Oxalic Acid SCHEMBL8192522 | 0.82 | HTR1F (0.45) | EGFRERBB2MAPTKDM4ENPC1 | |
| SCHEMBL8548601 | 0.67 | HTR1F (0.45) | HTR1F | |
| SCHEMBL8190120 | 0.67 | HTR1F (0.58) | MAPTKDM4ENPC1GALR3RAB9A | |
| SCHEMBL8550328 | 0.67 | FLT1 (0.37) | EGFRERBB2MAPTNPC1RAB9A | |
| Maleic Acid SCHEMBL8552223 | 0.66 | HTR1F (0.41) | MAPTNPC1RAB9AHTR1F | |
| Sulfuric Acid SCHEMBL8551754 | 0.66 | TMEM97 (0.43) | MAPTKDM4ENPC1GALR3RAB9A | |
| SCHEMBL8547156 | 0.66 | HTR1F (0.49) | MAPTNPC1RAB9AHTR1F | |
| SCHEMBL8551441 | 0.66 | ACKR3 (0.49) | EGFRERBB2MAPTHTR1FTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |