Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | SENP5 | Q96HI0 | 1/20 | 0.33 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.33 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8190943 | 0.86 | HTR1F (0.59) | HTR1FMAPTPOLBNPC1RAB9A | |
| Maleic Acid SCHEMBL8551457 | 0.86 | HTR1F (0.41) | HTR1FMAPTPOLBBCHETP53 | |
| Maleic Acid SCHEMBL8551151 | 0.77 | HDAC1 (0.36) | MAPTACKR3BCHETP53HDAC3 | |
| SCHEMBL8551502 | 0.72 | HTR1F (0.46) | HTR1FMAPTPOLBTP53CNR2 | |
| SCHEMBL8551891 | 0.70 | HTR1F (0.49) | HTR1FMAPTACKR3TP53CNR2 | |
| SCHEMBL8551441 | 0.70 | ACKR3 (0.49) | HTR1FMAPTACKR3MCHR1SENP5 | |
| Malonic Acid SCHEMBL8548925 | 0.69 | HTR1F (0.47) | HTR1FMAPTACKR3TP53SENP5 | |
| Maleic Acid SCHEMBL7143351 | 0.69 | HDAC1 (0.40) | HTR1FNPC1RAB9AHDAC3HDAC1 | |
| Oxalic Acid SCHEMBL8553970 | 0.66 | EGFR (0.41) | HTR1FMAPTNPC1RAB9A | |
| SCHEMBL8190120 | 0.65 | HTR1F (0.58) | HTR1FMAPTPOLBMCHR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |