Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8109544 | 0.82 | SMN1; SMN2 (0.44) | SLC6A2SLC6A4KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL8555243 | 0.81 | AKR1C3 (0.41) | SLC6A4KCNA5SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL8555184 | 0.81 | KCNA5 (0.40) | SLC6A4KCNA5KCNH2SMN1; SMN2CYP11B1 | |
| SCHEMBL8550969 | 0.80 | EPHX1 (0.46) | KCNA5KCNH2SMN1; SMN2ADRB2MAOA | |
| SCHEMBL8555652 | 0.79 | PPARG (0.41) | KCNA5KCNH2SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL8555291 | 0.78 | PPARG (0.43) | SLC6A2SLC6A4KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL8552624 | 0.78 | CYP19A1 (0.47) | KCNA5SMN1; SMN2CYP11B1CYP11B2ALDH1A1 | |
| SCHEMBL2496117 | 0.77 | SLC6A2 (0.61) | SLC6A2SLC6A4KCNA5KCNH2ADRA2A | |
| SCHEMBL5752973 | 0.76 | ADRA2A (0.60) | SLC6A2SLC6A4KCNA5KCNH2ADRA2A | |
| SCHEMBL8139574 | 0.75 | ALOX5AP (0.39) | KCNA5KCNH2SMN1; SMN2ADRB2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |