Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8593535 | 0.91 | CYP1A2 (0.41) | — | |
| SCHEMBL8593434 | 0.90 | KCNK3 (0.37) | POLBRAB9AKDM4EALDH1A1CNR2 | |
| SCHEMBL8813165 | 0.90 | BACE1 (0.35) | POLBRAB9AKDM4EALDH1A1CNR2 | |
| SCHEMBL8554981 | 0.83 | POLB (0.42) | POLBRAB9AKDM4EALDH1A1GPR88 | |
| SCHEMBL8592569 | 0.83 | POLB (0.39) | POLBRAB9AKDM4EALDH1A1GPR88 | |
| SCHEMBL8596274 | 0.81 | GPR88 (0.34) | POLBRAB9AKDM4EALDH1A1GPR88 | |
| SCHEMBL27520600 | 0.79 | CNR2 (0.39) | POLBRAB9AKDM4EALDH1A1GPR88 | |
| SCHEMBL8552407 | 0.74 | SLC1A2 (0.58) | ALDH1A1 | |
| SCHEMBL8594406 | 0.74 | CYP1A2 (0.39) | — | |
| SCHEMBL8440266 | 0.73 | ACE (0.46) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1197452-A | Azetidinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | claimed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |