Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551020 | 0.87 | ACE (0.43) | ACESLC1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8552407 | 0.85 | SLC1A2 (0.58) | ACESLC1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL8551199 | 0.84 | ALDH1A1 (0.43) | ACEALDH1A1PKM | |
| SCHEMBL8554773 | 0.82 | ALDH1A1 (0.54) | ACESMN1; SMN2ALDH1A1PKM | |
| SCHEMBL8620238 | 0.82 | ATM (0.43) | ACESMN1; SMN2ALDH1A1 | |
| SCHEMBL8552221 | 0.82 | MDM2 (0.44) | ACEALDH1A1PKM | |
| SCHEMBL8596008 | 0.79 | SNCA (0.37) | ALDH1A1 | |
| SCHEMBL8812094 | 0.78 | ALDH1A1 (0.40) | ACESMN1; SMN2ALDH1A1PKM | |
| SCHEMBL8557349 | 0.77 | L3MBTL1 (0.40) | ACEALDH1A1 | |
| SCHEMBL8552490 | 0.77 | ALDH1A1 (0.42) | ACEALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5990102-A | Substituted azetidin-2-ones for treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 1999-11-23 | — | — | US | claimed |
| CN-1197452-A | Azetidinone derivatives for treatment of atherosclerosis | SMITHKLINE BEECHAM PLC (GB) | 1998-10-28 | — | — | CN | disclosed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |