Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.51 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5641184 | 0.82 | NFE2L2 (0.53) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL4082035 | 0.80 | NFE2L2 (0.51) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL2084338 | 0.80 | NFE2L2 (0.55) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL4378934 | 0.80 | NFE2L2 (0.51) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL5765086 | 0.79 | NFE2L2 (0.51) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL9000315 | 0.78 | NFE2L2 (0.58) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL15157538 | 0.78 | NFE2L2 (0.47) | NFE2L2PLAURAB9ANPC1SMN1; SMN2 | |
| SCHEMBL29416506 | 0.76 | NFE2L2 (0.48) | NFE2L2PLAUPDGFRBPDGFRARAB9A | |
| SCHEMBL6765340 | 0.75 | NOS3 (0.45) | PLAURAB9ANPC1LMNAL3MBTL1 | |
| SCHEMBL27220459 | 0.74 | NFE2L2 (0.50) | NFE2L2PLAURAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0861245-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997019073-A1 | PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-29 | — | — | WO | disclosed |